African Neuro Trauma Mortality and Outcome
An African multi-centre study investigating the global burden of traumatic brain injury and its contribution to trauma-related mortality
Key Documents for Collaborators
The full ANTMOS study protocol
All the information you need for ethics
A useful tool to help collect data at your site
A 1-page summary of ANTMOS
Background
Injury is the most prominent contributor to global death and disability, and neurotrauma constitutes a significant proportion of those injury statistics, especially in low- and middle-income countries that face additional barriers to care. Neurotrauma consists of traumatic brain injury (TBI) and spinal cord injury (SCI). These injuries are often very severe and may cause long-term disability, which is currently poorly quantified making it difficult to adequately motivate for funding and further research to improve clinical care and patient outcomes. The African Neurotrauma Mortality and Outcome Study (ANTMOS) aims to map the proportion of trauma admissions created by neurotrauma, as well as the mortality and functional outcome of adult and paediatric neurotrauma patients in multiple African centres. This study addresses the paucity of African mortality and morbidity data, seeking to inform prevention strategies and to provide baseline values for future comparison.
Study objectives
Primary objectives: To determine the proportion of hospital admissions due to neurotrauma, as well as the overall trauma- and neurotrauma-related mortality and mechanisms of injury.
Secondary objectives:
- To assess functional outcome at discharge using the GOS-E.
- To compare functional outcome and disability at 6-month follow-ups to discharge in centres with 6-month clinical follow-ups as part of routine care.
Inclusion and Exclusion Criteria
Inclusion criteria: All patients admitted to the trauma ward of participating centres within their 30-day period, with all trauma definitions and dead-on-arrival included where trauma is suspected to be the cause.
Exclusion criteria:Non-trauma injuries, superficial injuries or patients who are not admitted to hospital.
Data Collection
Data will be collected using electronic case record forms (eCRF) via the REDCap platform. Each patient will be anonymised and identified by numeric codes. Data validation will be conducted by independent data validators at each site.
